Epigenetic silencing of GDF1 disrupts SMAD signaling to reinforce gastric cancer development
نویسندگان
چکیده
منابع مشابه
Smad signaling is required to maintain epigenetic silencing during breast cancer progression.
Breast cancer progression is associated with aberrant DNA methylation and expression of genes that control the epithelial-mesenchymal transition (EMT), a critical step in malignant conversion. Although the genes affected have been studied, there is little understanding of how aberrant activation of the DNA methylation machinery itself occurs. Using a breast cancer cell-based model system, we fo...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2015
ISSN: 0950-9232,1476-5594
DOI: 10.1038/onc.2015.276